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apalutamide will minimize the level or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with drugs which might be CYP2C19 substrates may result in reduce exposure to those prescription drugs.C: Use with warning if Rewards outweigh risks